The vascular endothelium has an important role in angiogenesis and vascular repair by producing regulatory substances, including NO, prostaglandin, endothelins, prostacyclin and angiotensin II. These regulatory factors regulate the blood flow to the penis by controlling smooth muscle contractility and subsequent vasoconstriction and vasodilatation. Generally, in erectile tissue, increased blood flow through the cavernosal artery increases shear stress and produces NO, which further relaxes the vascular smooth muscles and increases blood flow in the corpora cavernosa.54 These events cause penile erection. However, in ED, endothelial NO synthesis is reduced and there is increased endothelial cell death (Figure 2).55 Pathophysiology of Erectile Dysfunction and Ischaemic Heart Disease
There is insufficient information on the safety of vardenafil in men with the following health disorders: .
But if the symptoms are not properly diagnosed, it may lead to other major issues. Hence knowing symptoms and properly-getting it diagnosed with the sexologist, is the foremost thing to do to treat Erectile dysfunction.
Where erectile dysfunction is predominantly due to a physical cause, patients may describe a gradual onset of symptoms, which may occur across a variety of settings and different stimuli. Where the psychological component is the main factor, patients may describe a sudden onset in symptoms with erectile dysfunction varying dependent on the situation.
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A general physical examination will be performed to assess the development of your male sexual characteristics and to detect any abnormality of your penis or testicles. Your blood pressure, height and weight will normally be measured as part of this examination.
Since endothelial dysfunction, CVD and ED are closely associated in epidemiological studies, the question for clinicians is whether to recommend the man presenting with ED undergo a cardiovascular (CV) evaluation. Clearly, based on numerous studies, ED can be considered at least a ‘marker’ for possible further vascular disease or CVD.15 In their report, Vlachopoulos and coworkers make the point that the man presenting with ED, the clinician, is offered an opportunity to attempt to improve the health of the man by addressing lifestyle modification, and consider further vascular evaluation owing to the clear relationship between endothelial dysfunction, ED and CVD.19
Quit smoking.Cut back on alcohol (no more than 2 drinks per day).DO NOT use illegal drugs.Get plenty of sleep and take time to relax.Stay at a healthy weight for your height.Exercise and eat a healthy diet to keep good blood circulation.If you have diabetes, keep blood sugar well-controlled.Talk openly with your partner about your relationship and sex life. Seek counseling if you and your partner have trouble communicating. References
Jammwal said that strengthening the pelvic region can help a great deal. “KalariSutra is a set of 19 exercises which, if practiced daily, will help in rejuvenating your blood flow and bring sexual energy back into the pelvic region,” he said while demonstrating a set of exercises inspired from martial art form.
Other medical therapies under evaluation include ROCK inhibitors and soluble guanyl cyclase activators. Melanocortin receptor agonists are a new set of medications being developed in the field of erectile dysfunction. Their action is on the nervous system rather than the vascular system. PT-141 is a nasal preparation that appears to be effective alone or in combination with PDE5 inhibitors. The main side effects include flushing and nausea. These drugs are currently not approved for commercial use.
Johns Hopkins Bloomberg School of Public Health: “18 Million Men in the United States Affected by Erectile Dysfunction.”
Having a healthy sex life and enjoying sexual activity is a normal, enjoyable part of living. Regular pelvic exercises can improve sexual performance by preventing premature ejaculation, help maintain an erection and even eliminate ED.
ED is a very intimate and private condition. Most patients consult multiple sources of information for erectile problems: friends, the Internet, media, a sexual health shop, a pharmacist, a psychologist, or a medical doctor.
Doctors have not tested the PDE5 inhibitors in patients with retinitis pigmentosa, an eye condition that affects the retina and can cause blindness, and so caution is recommended if you have this health condition.
Traditional treatments for both problems revolve around lifestyle changes and drugs, Mr Myers and his colleagues said.
ED pills you take by mouth can have side effects. These can range from muscle pain and flushing to heart attack. DO NOT use these drugs with nitroglycerin. The combination can cause your blood pressure to drop.
If you can’t get or keep an erection that lasts long enough or is rigid enough for sex, you have erectile dysfunction.